An Exploratory Study of Factors that Affect the Performance and Usage of Rapid Diagnostic Tests for Malaria in the Limpopo Province, South Africa
- Malaria rapid diagnostic tests (RDTs) are relatively simple to perform and provide results quickly for making treatment decisions. However, the accuracy and application of RDT results depends on several factors such as quality of the RDT, storage, transport and end user performance. A cross sectional survey to explore factors that affect the performance and use of RDTs was conducted in the primary care facilities in South Africa.
Assessing the Risk of Self-Diagnosed Malaria in Urban Informal Settlements of Nairobi Using Self-Reported Morbidity Survey
- Because of the belief that Nairobi is a low risk zone for malaria, little empirical data exists on malaria risk in the area. The aim of this study was to explore the risk of perceived malaria and some associated factors in Nairobi informal settlements using self-reported morbidity survey.
Comparison of PCR-Based Detection of Plasmodium Falciparum Infections Based on Single and Multicopy Genes
- This study compared the diagnostic accuracy of three PCR-based assays that do not only differ in their sequence target, but also in the number of copies of their target region, for the detection of Plasmodium falciparum in 401 individuals living in a malaria-endemic area in Nigeria.
Haemoglobin and Haematocrit: the Threefold Conversion is Also Non Valid for Assessing Anaemia in Plasmodium Vivax Malaria-Endemic Settings
- It has been recently reported that the standard threefold conversion from haematocrit to haemoglobin underestimates the prevalence of anaemia and low levels of haemoglobin in children living in areas endemic for Plasmodium falciparum malaria. The data presented herein describes the experience in a malaria-endemic zone in northeastern Venezuela (state of Sucre), where a similar bias between haematocrit and haemoglobin in patients with Plasmodium vivax infection was found.
Malaria Diagnosis and Clinical Complications
- Same as title, discusses how malaria is diagnosed and the complications that it causes.
Malaria Microscopy, While the Gold Standard for Malaria Diagnosis, Has Limitations
- Efficacy estimates in drug and vaccine malaria trials are very sensitive to small errors in microscopy endpoints. This fact led to the establishment of a Malaria Diagnostics Centre of Excellence in Kisumu, Kenya. The primary objective was to ensure valid clinical trial and diagnostic test evaluations.
Malarial Pigment Haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not Stimulate Expression of Inducible Ntiric Oxide Synthase and Production of Nitric Oxide in Immuno-Purified Human Monocytes
- Purpose of this study was to analyse the effect of P. falciparum HZ and sHZ supplemental to treatment with IFN-gamma and/or a stimulatory cytokine-LPS mix on iNOS protein and mRNA expression in immuno-purified human monocytes.
Paracheck-Pf® Accuracy and Recently Treated Plasmodium Falciparum Infections: Is There a Risk of Over-Diagnosis
- An assessment of the accuracy of Paracheck Pf®, a malaria rapid diagnostic test (RDT) detecting histidine rich protein 2 was undertaken amongst children aged 6–59 months in eastern Democratic Republic of Congo.
Selective Activation of TCR- γδ+ Cells in Endemic Burkitt's Lymphoma
- The overlap in geographical distribution of Plasmodium falciparum malaria and endemic Burkitt's lymphoma (eBL) – an aggressive Epstein-Barr virus (EBV)-associated B-cell tumour occurring almost exclusively in the tropics – strongly suggests a link between the two
diseases. It is suspected that the polyclonal B-cell activation in P. falciparum malaria may precipitate a breakdown in homeostatic T-cell control of EBV-immortalized B-cell proliferation.